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objectif
Pharmacogenetic cross-over trial on the response to different Clopidogrel loading doses depending on the presence of the CYP2C19*2 variant
date de réalisation
2009
nombre de patients
109
nombre de centres participants
Monocentric (Pitié-Salpêtrière)
type de financement
Public (PHRC)
Référence
NCT00822666
Clopidogrel and Response Variability Investigation Study 2 (CLOVIS2)
To evaluate the role of the genetic variant 2C19*2 on the pharmacodynamic response as assessed by optical aggregometry and on the pharmacokinetic response as assessed by measuring active metabolites following an oral administration of a loading dose of 300/900mg of clopidogrel in patients with established coronary artery disease.
source clinicaltrials.gov
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