je fais un don
je fais un don
Terminée
objectif
Évaluer l’impact de la transfusion sur l’activation et l’agrégation plaquettaire, dans une série de mesures biologiques (T1 avant et T2 après transfusion ) réalisées dans les 2 groupes randomisés de l’essai REALITY (stratégie libérale de transfusion sanguine).
date de réalisation
2016
nombre de patients
93
nombre de centres participants
8 centres français
type de financement
Public (CRC 2016)
Référence
NCT02648113
Impact of Transfusion of Red blood cell on platelet Activation, aggregatioN and Systemic biomarkers with clinical Follow Up Studied in patients with anemia and Myocardial InfarctiON of the REALITY study – (TRANSFUSION-REALITY)
Anemia in patients with myocardial infarction (MI) is a relatively frequent issue, resulting in poorer outcome. There is equipoise regarding which transfusion strategy is best, and there is an international consensus on the urgent need for a randomized trial. The REALITY study hypothesize that a "restrictive" transfusion strategy (triggered by Hb <= 8 g/ dL) will be clinically non-inferior to a "liberal" transfusion strategy (triggered by Hb <= 10g/ dL) but will be less costly.
TRANSFUSION-REALITY is a biological ancillary substudy of the REALITY study evaluating impact of RBC transfusion on platelet activation, aggregation and systemic biomarkers of thrombosis and inflammation in a series of biological measurements (baseline at randomization (before the first RBC transfusion (T0)), after RBC transfusion (on the next day after randomization and/or transfusion according to the group (T1)) and at discharge (T2) from the cardiology service.
source clinicaltrials.gov
En cours
En cours
En cours
